O fualaau o le Cytotoxic o se kulupu o fualaau oona lea o loʻo faʻatatau i le taofiofia poʻo le taofiofiina o le faagasologa o le vaʻaia o le tino ma le tuputupu ae o mea fesoʻotaʻi.
O le a le taimi e faʻamaonia mai ai le faʻamalosi o vailaʻau?
O le vaega autu o le faaaogaina o fualaau faasaina o loo fesiligia o le togafitiga o le mama o le tino o loo faamatalaina i le tele o le vavaega o le tino (cancer, leukemia , lymphomas, etc.).
I se tulaga maualalo, o aʻafiaga o fualaau oona i totonu o lenei vaega e mafai ona vave gaogao faasolosolo o gaʻo ponaivi, paʻu, mucous membranes, epithelium o le gastrointestinal tract. O lenei mea e faatagaina ai le faʻaaogaina o vailaau faʻamalosi i faʻamaʻi masimmune (faʻamaʻi vai, scleroderma, lupus nephritis, maʻi o Goodpasture, suauu lupus erythematosus, ma isi).
I le avea ai o se vaega o togafitiga faʻapitoa, o vailaʻau cytotoxic e mafai ona faʻafofo tautala i foliga o laumei, capsules, poʻo le injections (inivetes, intraterterial, intraluminal, intravitreal). O le umi o le faagasologa o togafitiga e fuafuaina e le ogaoga o le maʻi, le lelei ma le gafatia o le vailaʻau.
List of cytotoxic drugs
E faʻamavae faʻamaʻi faʻamaonia mo le faʻamoemoega o le faʻatulagaga, ma o lenei faʻavasegaga e faʻapitoa, aua tele fualaau faasaina o le vaega lava e tasi ei ai se faiga uiga ese o le gaioiga ma e aoga tele faasaga i ituaiga eseese eseese o le mama. O le lisi sili lea o igoa o fualaau oona cytotoxic:
1. Alkylating fualaau faasaina:
- alkylsulfonates (Busulfan, Treosulfan);
- ethylenimines (Thiotepa);
- afuaga o le nitrosoureas (Nimustine, Lomustine, Carmustine, Mystophoran, Streptozotocin);
- chloroethylamines (Chlorambucil, Ifosfamide, Bendamustine, Cyclophosphamide, Melphalan, Trophosphamide).
2. Alkaloids o fualaau toto:
- podophyllotoxins (Teniposide, Etoposide);
- lafoga (docetaxel, paclitaxel);
- vinaalkaloids (Vindesin, Vincristine, Vinblastine, Vinorelbine).
3. Antimetapolites:
- tagata faʻataʻavale o le folic acid (Ralitrexed, Methotrexate);
- Ave faʻamalosi (Cladribine, Fludarabine, Pentostatin, Thioguanine);
- o le au o le pyrimidine (cytarabine, capecitabine, gemcitabine, fluorouracil).
4. Vailaau faʻamaʻi faʻamalosi faʻamalosi:
- anthracyclines (Doxorubicin, Daunorubicin, Epirubicin, Idarubicin, Mitoxantrone);
- isi vailaau faʻamaʻi (anti-antibiotic (mitomycin, bleomycin, plikamycin, dactinomycin).
5. Isi cytostatics:
- faʻasologa o camptothecin (Irinotecan, Topotecan);
- afuaga o le kapini (Cisplatin, Carboplatin, Oxaliplatin);
- isi (Temozolomide, Altrethamine, Estramustine, Amsacrine, L-asparaginase, Dacarbazine, Hydroxycarbamide, Procarbazine).
6. Faʻalavelave faʻasolosolo e tasi (Trastuzumab, Ederkolomab, Rituximab).
7. Honamoni cytostatic:
- antiandrogens (cyproterone acetate, bicalutamide, flutamide);
- progesins (Medroxyprogesterone acetate, Megestrol acetate);
- estrogens (Polyestradiol, Phosphastrol);
- antiestrogens (Toremifene, Tamoxifen, Droloxifene);
- inhibitors aromatase (Anastrozol, Formousan, Exemestane).
- LH-RH agonists (Gocerelin, Buserelin, Leiprolein acetate, Tryptorelin).
Cytotoxic agents mo pancreatitis
I faʻamaʻi tuga, e mafai ona faʻaogaina ai faʻamalosi (eg, fluorouracil) mo togafitiga. O le faiga o gaioiga o nei vailaʻau e fesootaʻi ma lo latou gafatia e taofiofia ai le fiafia tele o le tino o le tino.
Aafiaga Afua o Cytostatics
O aʻafiaga aʻafiaga i le togafitiga o le gataifale o:
- leiloa o lauulu;
- manava;
- anorexia ;
- taʻavale;
- vili;
- tiga o le ulu;
- vaivaiga maso;
- solia o le faasolosolo malie;
- valea fanau;
- atinaeina o le leukemia, ma isi.